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Interpretation of 1D & 2D NMR Spectra
Introduction
Introduction (1:51)
Chapter 1: NMR Signals
Table of Nuclear Spins (5:22)
Nuclear Energy Levels (7:56)
Macroscopic Magnetization Vector (16:29)
NMR Frequency Table (7:10)
Generation of NMR Signal (9:21)
Coil Shapes (3:19)
Shielding (28:01)
Chemical Shift Anisotropy (23:03)
Chapter 2: Proton Chemical Shifts
Typical Proton Chemical Shifts (12:48)
Proton Additivity Constants (6:38)
Chemical Shifts for Methylene Groups (3:27)
Additive Shielding Increments for Olefins (4:06)
Substituent Chemical Shifts in Benzenes (1:58)
Hydrogen Bonding (8:15)
Solvent Effects on Chemical Shifts (6:06)
ASTM Standard Practice for Referencing (5:40)
Chapter 3: Carbon-13 Chemical Shifts
Factors (15:30)
Typical 13C - Chemical Shifts in Organic Compounds (6:19)
Substituent Effects and Additivity Rules (42:10)
Proton and 13C Chemical Shifts of Some Unsaturated Cyclic Systems (28:35)
Problem Solving (2:58)
Chapter 4: Proton Couplings
Chloroform 1H Line Shape and Hump Test (5:47)
Energy Level Diagram for a Coupled Two-Spin System (8:02)
Energy Levels in an AX System (9:19)
Definition, Signs and Simple Theory of Scalar Coupling (13:56)
First-Order rules and Pascal's Triangle (17:28)
Splitting Triangle When I = 1 (3:58)
Coupling with Two or More Different Nuclei (10:27)
Weak Coupling (7:15)
Strong Coupling (3:33)
Deviation From First-Order Rules (2:16)
60, 90, and 220 MHZ 1H Spectra of n-butylvinylether in CDCl3 (3:07)
Characteristic Proton-Proton Coupling Constants (1:44)
Selected Values of Vicinal Coupling Constants in Olefinic & Aromatic Systems (6:35)
Selected Values of Vicinal Coupling Constants across Saturated Bonds (0:33)
The Effect of Substituents (4:46)
Selected Examples of Geminal Coupling Constants (1:35)
Selected Examples of Long-range HH Couplings (0:58)
Couplings Through Four Saturated Bonds (1:47)
Crotonaldehyde Spectrum at 300 MHz (20:47)
Heteronuclear Coupling Constants (2:25)
2D Homonuclear J-Resolved Spectra (9:49)
Methyl Region of the ID Proton Spectrum (4:12)
2D Homonuclear J-Resolved Spectrum of Coumarin (8:57)
Chapter 5: Carbon-13 Couplings
One-Bond Proton-Carbon Coupling Constants (26:09)
Two- and Three-Bond Proton-Carbon Coupling Constants (2:13)
Carbon-Carbon Coupling Constants (1:43)
Carbon-Heteronuclear Coupling Constants (0:54)
Carbon-Phosphorus Coupling Constants (0:56)
Structural Features and Carbon-Phosphorus Couplings (0:22)
Proton-Coupling (4:28)
Chapter 6: Homonuclear Decoupling and Homonuclear Correlations
Proton-Proton Decoupling (27:38)
Homonuclear Correlations (42:45)
An Example of lmproper Phase Cycling (2:20)
2D INADEQUATE (9:57)
Intentionally Folded INADEQUATE Spectra (8:58)
Problem Solving (6:34)
Chapter 7: Heteronuclear Decoupling and Proton-Carbon Correlations
Selective Decoupling (6:18)
Heteronuclear Chemical Shift Correlation: Coumarin in CDCl3 (6:29)
Indirect Detected Heteronuclear Correlation Spectroscopy (1:38)
Comparison of HMQC and HSQC spectra (0:51)
Accidental Proton Shifts in HETCOR (1:13)
Heteronuclear Correlation Via Long Range Coupling (4:20)
Chapter 8: Introduction to the NOE
Scalar vs. Dipolar Coupling (2:38)
Proton-Decoupled Carbon Spectrum (9:31)
Pamoic Acid - Proton Spectrum (6:30)
Pamoic Acid - NOE Difference Spectrum (10:45)
Chapter 9: Non-Equivalent Nuclei
AA'XX' Spectrum (14:58)
Analysis of an AA'XX' System (0:54)
Magnetic Equivalence Problems (18:02)
Acetylene - 1,2 - 13C2 Proton Spectrum (0:37)
Non-Equivalent AB Protons (5:15)
Spectrum of Trimethylcitrate (5:47)
Virtual Coupling (2:59)
Chapter 9 Examples
Example of Structure Determination Using NOE Difference (17:03)
Chapter 10: Strong Coupling
Calculated AB Spectra (4:37)
The 60 MHZ 1H Spectrum of Abel's Ketone in CDCl3 (0:38)
Crotonaldehyd Spectrum at 60 MHz (1:16)
Calculated AB2 Spectra (2:21)
The 60 MHZ 1H Spectrum of 2,6-Dichlorophenol (1:46)
Analysis of an ABX Spectrum (1:23)
The 60 MHZ 1H Spectrum of Malic Acid & the CH2CH Proton of a Substituted Cycloproprane (0:22)
The Spectrum of Malic Acid at Different Field Strengths (0:41)
Strong Coupling in 2D INADEQUATE Spectra (3:35)
Strong Coupling Effects in 2D J,(delta) Spectra (6:16)
Example Problem (13:09)
Chapter 11: Shift Reagents
Spectrum of an Optically Active Isomer; Effect of Chiral Shift Reagent on Pure R-Isomer; Spectrum of a Racemic Mixture; Effect of Chiral Shift Reagent on Racemic Mixture (2:07)
Chapter 12: Spin Lattice Relaxation
Basic Relaxation Concepts (5:04)
Longeitudinal Relaxation Time, T1 (8:08)
Measurement of T1 (1:39)
T1 Spectra (4:55)
Relaxation Mechanisms (6:15)
Dipole-Dipole and Spin Rotation Contributions (3:36)
Contributions to Dipole-Dipole Relaxations (19:52)
Electric Quadrupole Relaxation (1:09)
Effect of Correlation Time on O-17 Spectra (3:50)
Effect of Anisotropic Overall Motion (1:25)
Some Characteristic 13C T1 Values (2:37)
T1 Data for Aniline in different Solvents (0:23)
Effect of Cr (III) and Cu (II) (6:49)
Chapter 13: Heteronuclear NOE
Effect of NOE on Integration (6:05)
Nuclear Overhauser Enhancement (6:05)
Measuring the NOE (3:27)
Coupled spectra With NOE (1:22)
Pulse Sequence in Gated Decoupling Experiments (7:04)
Incomplete NOEs (5:57)
Measuring T1DD (2:29)
Assignment of Quaternary Carbons in Benzonitrile (1:55)
Integration of Carbon Spectra (8:03)
Chapter 14: Homonuclear NOE
Dependence of Maximum Homonuclear NOE on Correlation Time (3:53)
Reduction of the Steady-State NOE with Distance (0:35)
NOE in Three-Spin Systems (5:23)
Dependence of NOE on Correlation Time and Mixing Time (6:49)
NOESY and ROESY Peaks vs. Correlation Time (1:35)
Final Problems And Answers
Problem 1: Sulcatol (11:39)
Problem 2: C8H9NO2 (8:15)
Problem 3: Structure Elucidation of an Unknown Hydrocarbon (4:30)
Problem 4: Pamoic Acid - Make all carbon line assignments (6:02)
Problem 5: Tripeptide - Make proton and carbon line assignments (13:40)
Problem 6: C18H20O6 - Make proton and carbon line assignments (8:59)
Conclusion
Farewell (0:35)
Heteronuclear Chemical Shift Correlation: Coumarin in CDCl3
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