Although a basic knowledge of chemical shifts and very simple interpretation of 1st-order spectra will be assumed, the general features of proton and carbon spectra will be reviewed with emphasis on the use of chemical shifts and coupling constants for the identification of unknown compounds. This will be followed by the use of proton decoupling procedures, magnetic non-equivalence, relaxation time measurements, and NOE. The second portion of the course will concentrate on the general features and interpretation of 2D homo- and heteronuclear J-delta and chemical shift correlation spectra. At the end of the course, six final structure problems demonstrate lessons learned throughout the course using both 1D and 2D spectra.
Your Instructor
Dr. Traficante obtained his Ph.D. in 1962 from MIT in the field of
synthetic organic chemistry. For 10 years he was
Director of the NMR Lab at MIT, and then held the same position at Yale University. Serving as the Director of Chemical Instrumentation at the National Science Foundation (NSF), he pioneered multi-nuclear instrumentation. He
has built probes, reassembled spectrometers, and developed new software
programs to enhance the signal-to-noise ratio and the resolution of NMR
spectra. He received a Letter of Commendation from the Chemistry Division when he left the NSF to return to teaching.
At NMR Concepts, his current research in the areas of structure determination, instrumentation and data processing provide him with knowledge and expertise that are applicable to a broad audience. His organic chemistry background, plus his expertise in electronics, gives his lectures a special depth and appreciation for the field. Dr. Traficante is known throughout the world as an outstanding educator.
Course Curriculum
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StartTypical Proton Chemical Shifts (12:48)
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StartProton Additivity Constants (6:38)
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StartChemical Shifts for Methylene Groups (3:27)
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StartAdditive Shielding Increments for Olefins (4:06)
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StartSubstituent Chemical Shifts in Benzenes (1:58)
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StartHydrogen Bonding (8:15)
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StartSolvent Effects on Chemical Shifts (6:06)
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StartASTM Standard Practice for Referencing (5:40)